Sanctuary

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Both manga are about changing Japan. Read Sanctuary for a hardboiled crime thriller look at Japanese politics populated by the manliest men in manga, with emphasis on yakuza involvement. Read Akumetsu to see Japanese politics blown up and eviscerated by a happy-go-lucky lunatic, with emphasis on unrestrained trashy violence, involving at one point a wheelchair kitted out with knives goring a politician to death. 

Both are about politics. Both protagonists criticize the government's policies in their own ways. 

Politics, corruption... Japan needs to change. Both manga focus on such an equation where the protagonists attempt to make a stand against the corruption of Japan and change it for the better. Sanctuary differs being an intense crime thriller, where two brothers make use of their superior intelligence to topple both the political and criminal battlefield. While Akumetsu has a complete maniac tearing up the world and showcasing his twisted love of violence and brutality. Overall, both manga are some of the manliest stories in existence that will ensure to appeal to anyone who enjoys stories with characters attempting to enact a drastic change on the world. read more 

1.Both of them have characters which have the ultimate aim of changing the state of Japan 2.Both of them have characters who are willing to do things the dirty way so that the "Ends will justify the means." 

Sanctuary is mostly a yakuza manga and I'm recommending this over Akumetsu cause they're similar, however Sanctuary tackles issues regarding Japan's half-corrupt political system in a more realistic and overall in a better course of action. Both have incredible manipulative MCs which has really been a sought-after element lately, really makes you wanna root for them and hope their plans execute correctly.  

The two main characters are a police officer and a gangster. They hate the corrupted society that they live in. 

Similarities - Both have the same idea: black and white, good and bad, underground and surface. Two guys are working toward a big goal from completely opposite sides. - Their connection stays hidden from everyone else, keeping things secret. Differences - Ouroboros focuses more on solving crimes and mysteries, while Sanctuary is about changing society. - Ouroboros sticks mostly to the two main characters, but in Sanctuary, the groups and side characters on both sides get more involved in the story. 

Targeted at a mainly male audience, filled with violence and bloodshed. Both focus on bending certain societal norms and have things to do with the govt., prison etc. Great indicators of how cruel the society is. 

Both involve one person "chasing" another person for their crimes and corruption. This is seen throughout Death Note and is only seen in the second half of Sanctuary. Both also involve highly intelligent and manipulative characters - with interesting points of view that make you wonder if these characters are really evil at all.