Futatsu no Spica
Twin Spica

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Obviously, both of them are about characters that have dreams of becoming astronauts and going through training to become one, though there is a lot more to this recommendation than just that. They are both life stories about the people you meet along the way and the struggles that you must overcome. These include the friends that you make, the family that support you, the mentors that provide you with guidance and those that stand against you and your dreams. These two manga contain a lot of tragic scenes in addition to multiple heart-warming scenes. I think fans of Space Brothers would enjoy the shorter, yet sweeter Twin Spica and fans of Twin Spica will get a lot out of the longer and more in-depth Space Brothers! read more 

Two stories with characters that dream to become astronauts and show the process of becoming one, the drama in those series are very emotional and nicely handled and it's very easy to root for their objectives. 

Twin Spica and Voices of a Distant Star are two sci-fi seinen manga with a relatively slow paced story. The main character is a middle school girl about to enter high school who knew a boy prior to the events of the story. Both manga are centered on some melancholic-feeling drama and the topic of space travel, and the art is very beautiful. 

Fruits Basket and Twin Spica are two manga series about an innocent, brown-haired girl who has also lost her mother due to an accident. Despite that, she manages to keep some hope with some ambitions in mind. The story follows her daily life with the people she meets, but there are also some supernatural elements (there's a curse that FuruBa's protagonist has to hide, while Twin Spica's protagonist is the only one who can see a ghost that follows her) within a fairly tragic story. 

One chapter in Twin Spica set in the past came to mind as I was reading Socrates in Love, as both that and the latter manga as a whole feature a tragic relationship of star-crossed students. Said relationship is recalled through both manga as a memory, as Twin Spica had this element as kind of a one-shot chapter and Socrates in Love starts off with the main character recalling the past, which leads into the story. Even outside of the one chapter in Twin Spica has somewhat of the same melancholic, slow vibe as Socrates in Love. 

Yu-Gi-Oh and Twin Spica are two fantasy-supernatural manga aimed at men (the former is shounen while the latter is seinen). The main character is a young high school freshman who is really small, somewhat shy, always thinks of others, and is constantly put to the test. The protagonist is followed around by a mysterious spirit whose past is featured later on. Twin Spica is definitely more slower-paced and less fantasy/action-packed, but the friend groups within these two manga feel similarly wholesome. 

A School Frozen in Time and Twin Spica are two manga series aimed at boys centered around a group of somewhat tight-knit high school students, many of which have fairly tragic backstories that are gradually revealed throughout the story. There are some supernatural elements as the former features students unable to exit the building, while the latter has a ghost as one of the main characters. There is also a surprising amount of blood, so proceed with caution. 

Astra Lost in Space and Twin Spica are two manga series aimed at boys themed around sci-fi, specifically space. The story is a bit of a coming-of-age tale as we see a group of high school students meet and grow from their experiences with each other, though Astra adds in a survival adventure plot element to the mix. Characters bond with each other in surprising ways that seem believable, and the gradual reveals of many of these characters' backstories will be sure to tug at the heartstrings. 

Twin Spica and Full Moon wo Sagashite are two manga series focusing on a young girl and her aspirations (Twin Spica's about astronauts while Full Moon's about pop stars). But these two stories are much darker and deeper than at first glance— there is lots of drama, mentions of death, some romance, and tragic relationships. Both main characters even have a dead mother and deal with some harsh truths that might get in the way of their aspirations. 

Both are astronomy themed anime that focuses on space travel and also shares a cheerful mc who in spite of their hardships they still manage to preserve and form bonds with other members of various personalities with their own reasons on why they travel space.