Saijaku Tamer wa Gomi Hiroi no Tabi wo Hajimemashita. @comic
The Weakest Tamer Began a Journey to Pick Up Trash

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I reached 50 on the other list

5/27/2022 Note: Unfortunately, 50 on both lists won't be enough to include every Otome Isekai in existence. This genre has grown into a beast.

A selection of fantasy and supernatural manga that have a child (or child-like being) as part of the main cast. Includes some reincarnation / isekai.

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Tags for searchability: Children, Cute kids, Child Main Characters, Child MCs, Child Protagonists

If there's a slime we go #spottheslime

Lead characters that are unreasonably detested and/or mistreated. Also Abused, Cursed, Despised, Isolated. Includes Revenge, Heartwarming/Healing tag.

(PART 1) https://myanimelist.net/stacks/36917

Additional (currently no MyAnimeList page):
-(Japanese Webtoon) Noroware Reijou wa Seinaru Koushaku to Hangyaku suru / The Rebellion of the Cursed Lady
-(Japanese Webtoon) Anata ga Watashi no Zetsubou wo Negaunara / If You So Desire My Despair
-(Japanese Webtoon) Ai wo Kureta no wa Shinigami Koushaku deshita / The One Who Gave Me Love Was The Duke Of Death
-(Japanese Webtoon) Junketsu wo Ushinatta Seijo ga Ai ni Furetara / When the Broken Saintess Touches Love
-(Japanese Webtoon) Kyouai to Junai / Between Yearning and Obsession
-(Japanese Webtoon) Dorei Shoujo wa Shirogane no Ryuu ni Dekiaisarete / The Silver Dragon's Bride
-(Japanese Webtoon) Seiryaku Kon Kougou wa Fukushuu no Doku ni Saku / Vengeful Weapon, Tears of Poison
-(Japanese Webtoon) Mikaeri wa Motomete Inakatta / Angel of the Golden Aura 38/
-(Japanese Webtoon) Sekkaku Reijou ni Hyoui Shita no ni Sude ni Yarakashita Nochi deshita! / I Woke Up As a Notorious Troublemaker!
-(Japanese Webtoon) Nullitas: Itsuwari no Hanayome
-(Manhwa) New Suitor for the Abandoned Wife / Abandoned Wife Has A New Husband (Submission Denied, on anime-planet)
-(Manhwa) The House of Diana's Choice / Who Do You Like More, Mom or Dad
-(Manhwa) Countess and the Blade
-(Manhwa) Too Cute to Handle / You Are So Cute
-(Manhwa) From Misery to Majesty
-(Manhwa) Once Wicked, Always Wicked
-(Chinese Manhua) Villainess No More (Submission Denied, on anime-planet)
-(Manga) Akuyaku no Oujo ni Tensei Shitakedo, Kakushi Chara ga Kakuretenai / I Reincarnated as a Villainous Princess, but the Hidden Character Is Not Hidden