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If you liked Trigun add

...then you might like Trinity Blood add

Both of the animes have fun loving, seemingly silly main characters who are in fact beings with powerful abilities. Also, both main characters have evil brothers that seek to destroy the world. The similarities really start to become apparent during the last 10 episodes of trinity blood. If you like Trinity blood, you'll probably like Trigun, but it doesn't necessarily work the other way around. Trigun is superior to Trinity blood imho.