Futsutsukamono no Ani desu ga
My Brother the Shut-in

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contains any story that mentions the concepts of

Any form of "Gender Dysphoria
Crossdressing
Transgender
Otoko no Ko
Femboy

Keyword: social anxiety, hikikomori, NEET, inferiority complex, autism, introvert, recluse, social outcast, shy characters, unsociable characters, awkward male lead, awkward female lead, clumsy protagonist, loner protagonist, unpopular protagonist, dandere, bookworm, misfits, nerd, nerdy female lead, insecure, anxious characters, lonely people, naive female lead, innocent female lead, diffidence, social isolation, solitude, socialisation, narcissism, psychopath, sociopath, anti-social protagonist, misanthrope, Asperger syndrome, schizoid personality disorder, embarrassing situation, loneliness, mental illness, otaku, crybaby male lead, depression, unrequited love, weak male lead, antihero, antiheroine, social phobia, shy protagonist, socially awkward character, socially clueless character.

Manga focusing on adult characters in their twenties, thirties etc who are working in the workplace or maybe unemployed.
Slice of Life, Drama or Romance. Some are like "adult coming-of-age".

A seinen manga means a comic published in a magazine targeted towards the adult male demographic in Japan.

Shounen manga created by women: https://myanimelist.net/stacks/41045

A seinen manga means a comic published in a magazine targeted towards the adult male demographic in Japan.


A josei manga means a comic published in a magazine targeted towards the adult female demographic in Japan.