Houtai Koushaku no Kekkon Jijou
The Marriage of the Unseen Duke

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Lead Character in romance/family-oriented story that are Blind, Deaf, Mute, or hold other Physical Disability (Wheelchair, Amputated Limb) for a large portion, if not permanently, of the story.

Mind-reading Lead Character in Romance/Family Oriented Story
https://myanimelist.net/stacks/37295
Misunderstood Leads in modern romance/school
https://myanimelist.net/stacks/36991

Lead Characters misunderstood/adored by people around them in fantasy/isekai
https://myanimelist.net/stacks/36957

Additional (currently no MyAnimeList page):
-(Japanese Webtoon) Kyouai to Junai / Between Yearning and Obsession (Mute Female Protagonist)
-(Manhwa) I Grabbed the Leash of the Blind Beast (Blind Male Lead)
-(Manhwa) Just Kill Me Now / No More Regrets, Just Kill Me (Mute Female Lead)
-(Manga) Party wo Oidasareta Motoyushashibono D Rank Bokensha Koe wo Nakushita SSS Rank Mahotsukai Bishojo wo Hiro Soshite Iyasareru / How the SS-Rank Sorceress Who Lost Her Voice Healed a D-Rank Adventurer Who Lost His Confidence (Mute Female Lead)

my personal favorites, includes both shoujo and josei.

falls in to the category of loveydovey girls (either as mc or "background" charas) who are;

-hopeless romantics
-extremely in love (in a healthier way)
-slightly obsessed (just a bit too much)
-fangirls
-straight up f@king delusional !!