Kirakira to Giragira
My Destiny Romance with Violence

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Here are some seinen manga recommendations with good stories that are a gem!

Only include those that are still ongoing

Some that aren't listed on MAL:

* Gradually Close to the Heart (CN)
* The Stars and I (CN)
* Day by Day (KR)
* First Love Operation (KR)
* Osananajimi ni Modoritai Bokura (JP)
* Ba-Couple? Iie Baka desu. (Coupledom 101) (JP)

There are some entries where "childhood friend" is a bit loose (aka, middle/high school friends and together later as adults). I prefer the long-term best friend types, as well as the ones where, even though it was a short time, they made a lasting impact on the other.