Human Lost: Ningen Shikkaku

The reason as to why I'm making this recommendation is odd. Because two of these works aren't the same at all... except they are, well kind of...Because of the title. "Ningen Shikkaku" also known as "No Longer Human" is a work done by Osamu Dazai in the 1940s. It was essentially the last work he did before he left this world by commiting suicide. Essentially 5 of the episodes in this anime should've been the movie I'm recommending [for different purpose], as they are directly adapted from Dazai's work. Compared to the movie, I think you'll find this series (Aoi Bangaku) a lot more interesting. Aside from the fact that Aoi Bangaku is directly from the manga, the first 5 episodes anyway, I think this series has a lot more to tell you as a viewer. It's a shame that one became a movie and not the other. Osamu Dazai would be ashamed if he was still here. read more 

In both of those movies, human enhancement in a cyberpunk setting is used to philosophise about what it means to be a human.