 If you liked
World Teacher: Isekaishiki Kyouiku Agent
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 ...then you might like
Murabito desu ga Nani ka?
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1) Both main character died and were reincarnated in a fantasy world
2) Both main character are hard-working protagonist
3) Both main character make an unnatural effort and become the strongest in the world.
4) Both main character have a "debuff" since the beginning of the story