 If you liked
Apothecarius Argentum
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 ...then you might like
Hakushaku Cain Series
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Both stories revolve around the use of poisons and power struggles. Both have tragic circumstances around the deaths of characters important and supporting to the main character. Both involve family lineage and succession. Hakushaku Cain Series is more gothic styled with a male protagonist, while Apothecarius is more feudal/medieval style with a female protagonist and a side plot of romance. Yet, both have a melancholy flavor.