 If you liked
IS: Otoko demo Onna demo Nai Sei
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 ...then you might like
Hikari to Tomo ni...: Jiheishouji wo Kakaete
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Both titles help the reader learn about a real medical condition that many people know nothing about through the story of a family. A child with this unusual condition is born to an unknowing family who slowly learns how to take care of them and love their differences, despite the trials they face for being different.
Realistic characters with "real-world" problems; raising a child who is different.