 If you liked
Meteor Methuselah
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 ...then you might like
Aegis
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Immortal Rain and Aegis are two great mangas who share many similar plot elements: Two childhood friends who grew up together in a orphanage, and they were both very close to a girl there, (one of the boys even had love feelings for her) but later they are taken from the orphanage and a sudden unexpected twist happens: one of the three betrays the other two, and because of that the other two end up in a cruel fate connected to some organizations that make weird experiences with children.
Years pass and one of the boys befriends a lively girl, but then his childhood friend
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