 If you liked
Hoshi no Koe
|
 ...then you might like
Sekai no Chuushin de, Ai wo Sakebu
|
Both are somber stories with lots of nice art and character designs and also both deal with pretty bad illnesses as well too.
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Recommended by Disapeared_Ghost
Socrates in Love and Voices of a Distant Star are both manga aimed at older audiences (the former is josei while the latter is seinen) that feature a budding relationship between a young girl and a young boy that unfortunately gets cut off due to circumstances beyond their control, like long-term distance or life-threatening illness. As expected of a somewhat star-crossed romance, the story (and in some ways, some of the art as well) feels somewhat melancholic and lonely, perfect for someone looking for something bittersweet.