 If you liked
Uchuu Kyoudai
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 ...then you might like
Shiori Experience: Jimi na Watashi to Hen na Ojisan
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"It's never too late to chase your dreams"
Both of these stories encompass this very theme, despite looking and feeling vastly different from each other. Both are also enjoyable, feel-good seinen mangas with just a teeny-bit of romance sprinkled through out the story. Though Space Brothers is more grounded in reality, while Shiori Experience is more supernatural and wacky in nature; these two give off the same vibes.
If you like to read to get inspired, then I highly implore you to read Shiori Experience as well.
Shiori Experience also has Kurt Cobain and Jimi Hendrix in it, so...
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Recommended by Loi_Pako03