 If you liked
Witchblade
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 ...then you might like
Mnemosyne: Mnemosyne no Musume-tachi
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Chalked full of Action and ready to kick ass! Both series have a Female protagonist who has to do dirty work. While Witchblade has the protagonist wielding a special "power" called the Witchblade, Mnemosyne has the protagonist wield a power of Invulnerability/Regeneration. Mnemosyne is a bit more gory than Witchblade but its an Excellent anime by my standards. Mnemosyne is still currently Airing (at a slow rate) but the 3 Episodes that are currently out are a must SEE!
For the guys: Witchblade being the boob-a-licious anime it is, Mnemosyne has a bit of nudity here and there. so 18+! (NOT HENTAI >=O )
~Enjoy
Weird ancient power a woman can only wield -> protagonist (voiced by Noto Mamiko in sub) constantly hunted down by a creepyass dude who wants her power (or her *for* her power) -> seems there are others like her; some psycho, some helpful.
Oh, and boobs & LesYay galore.
Both of these great anime involve powerful woman protagonists as main characters who are in tight struggles against the consequences that these powers bring. Although Mnemosyne is more sinister, both contain intense fighting scenes and have interesting plots. What's more, the two main female characters from these anime are voiced by the same seiyu.