 If you liked
Trigun
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 ...then you might like
Monster
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Their setting is entirely different since Trigun is westernized and is set on a fictional planet based on American Old West, whilst Monster is set in Europe with real life locations.
What these two anime have in common, is the apex of psychological drama, both of these masterpieces reach (sooner or later) as the story progresses. Several characters from Trigun are very similar to those in Monster. Nicholas D. Wolfwood and Wolfgang Grimmer first come to my mind. Then Legato and Johan, although Legato isn't the main villain. Nina and Meryl (well, kind of) .Both series feature the twin brother as the main antagonist. Both
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Both shows talk about the value of human life and have villains trying to prove the protagonists philosophy wrong. Both protagonists are kind-hearted men who are put in a difficult position where they have to decide between their morals and the people they care about.
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Recommended by KnightMare18