 If you liked
Noein: Mou Hitori no Kimi e
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 ...then you might like
Ergo Proxy
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Noein does the job of raising the philosophical questions and Ergo Proxy answers them in its own unique style - these two anime complement one another and are both masterpieces rich with discussions of 'existence'.
It seems that when I watch both series, I couldn't help but notice the similarities of the style, plot, and feeling of both stories.
There's sci-fi themes and a dystopia like feeling dealing with the past, present, and future. Both series are also intellectual and surrounded in mystery behind the scenes.
The main characters have special abilities and gifted. There is also sparks of romance in both series but also with tragedy, emotions, drama, and some comedy (less so in Ergo Proxy). If you're looking for some otherworldly anime, then these two might be worth a shot.