 If you liked
Trigun Stampede
|
 ...then you might like
Metallic Rouge
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Both are sci-fi set on post-cataclysmic planets (Noman's Land and Mars) with deserts and cities where various factions and bandits run wild.
Each has a non-human protagonist (Vash, a plant and Rouge, a Nean) who teams up with humans in journalism/investigation professions (Naomi and Meryl).
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Recommended by Fortress_Maximus
The setting for both anime take place on other planets with main characters who appear to be normal humans but turn out to be not (Rouge is a nean and Vash is a plant). The MCs also have a journalist/investigator-type sidekick (Naomi Ortman in Metallic Rouge and Meryl Stryfe in Trigun Stampede). The division between normal humans and the "artificial" humans (neans or plants) is also a central theme in both anime.
Metallic Rouge has a slightly more mysterious element to it with a MC whose values and motives are not clear to start, whereas Vash comes off as a more straightforward character