 If you liked
Tenkuu no Shiro Laputa
|
 ...then you might like
Galilei Donna
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In both you have kids (or at least young adults) who embark on a journey to find something that doesn't have to fall in the wrong hands.
The kids/young adults are chased by a shady organization and a bunch of carefree sky pirates,
and are descendants of important people.
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Recommended by Silent_Chime