If you liked
Vanitas no Karte
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...then you might like
Undead Girl Murder Farce
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The setting is Europe in both series with elements of mystery and fantasy. The main characters are looking for something they lost or want and resolve mysteries while getting close to their goal.
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Recommended by hinfatuation
Similar gothic historical European vibe and aesthetic. Both have supernatural elements, morally complex characters, and a protagonist that's haunted by human experimentation.
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Recommended by Floral_soap
The setting of both anime is 19th-century Europe with supernatural beings (in Vanitas no Karte mainly vampires; in Undead Girl Murder Farce, it's more diverse, but vampires also show up). Morally gray characters solve different cases while coming closer to their own personal goals. Both anime have characters who are victims of human experimentation. Both series state at the very beginning that one of the main characters will die at the end of the story, killed by the other one.
Similar historical Victorian Europe setting, with vampires and other supernatural creatures, and a MC group that solves mysteries