 If you liked
Futatsu no Spica
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 ...then you might like
Yu☆Gi☆Oh!
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Both have a focus on friendship, a young mc that has been through a lot in the story and also elements of supernatural as well too from someone older than they are.
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Recommended by Disapeared_Ghost
Yu-Gi-Oh S0 and Twin Spica are two fantasy anime aimed at men (Yu-Gi-Oh is shounen while Twin Spica is seinen). The main character is a somewhat shy high school freshman who is fairly small for their age and is constantly tested by those around them; they are also followed around by a mysterious spirit who helps them in some way. While Twin Spica is definitely more slower-paced and less action-packed than Yu-Gi-Oh, both anime have a similarly wholesome friend group as the main cast and the OPs feature great songs.