 If you liked
Ookami to Koushinryou
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 ...then you might like
Kino no Tabi: The Beautiful World - The Animated Series
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They are similar in aspect that both are adventure anime in which the main 2 characters go from country/city to country/city, meeting new people on their journey.
The biggest difference between the two is that Spice and Wolf also features a romantic plot between the main 2 characters.
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Recommended by JokerDBlue