 If you liked
Ookami to Koushinryou
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 ...then you might like
Junketsu no Maria
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These two are rather misleading, to begin with. FAR more so in the case of Maria since the females dress like strippers (fits the 'heretic witches' angle + a succubus, but still...) and a great deal of emphasis is placed on the heroine's virginity; often comically so. In the case of Spice & Wolf, it was just the heroine - Howo - being naked when she was introduced that set off early furry alarms... before she proceeded to put on and not remove clothes.
They do what few to no other anime do: introduce a fantasy (animal 'Gods' in S&W; witches in Maria) element, then
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Recommended by AironicallyHuman
Anime is set in alternative medieval, while in Junketsu no Maria has strong female lead Spice and Wolf has interaction between male trader Lawrence and female old wolf pagan god Holo. Both have few strong side characters that adds more deeper understanding to the story and main characters.