 If you liked
Ansatsu Kyoushitsu
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 ...then you might like
Ranpo Kitan: Game of Laplace
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it's from most of the crew of assassination classroom, features a male main character that looks and sounds like a girl, and features a dark story revolving murder and a thread to mankind in a school setting.
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Recommended by NintensityCrowds
Main character is an androgynous boy often confused with a girl. High school/highschoolers kind of setting. Friendship. Teacher and murder go hand in hand.
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Recommended by crownedkags