 If you liked
Wolf's Rain
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 ...then you might like
Ginga Densetsu Weed
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I'd reccomend those who enjoyed the fantasy and animal aspects of Wolf's Rain try on Ginga Densetsu Weed for size. They both use animals as main characters, and they both have one of those scripts that can take you from a laugh, to bawling on the floor and back again in the blink of an eye. Although Ginga is bloody and violent, at times it does seem more oreinted towards a younger audience than Wolf's Rain is, but overall they're very similar.
both have animals looking/ saving there paridise
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Recommended by leeismyking3
The only two animes I know with the main characters as wolves (or dogs, in Ginga Densetsu Weed's case..)