 If you liked
Tengen Toppa Gurren Lagann
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 ...then you might like
World Destruction: Sekai Bokumetsu no Rokunin
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Same idea with beastmen ruling over humans.
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Recommended by sexylittleotter
Changing the world is not easy and in both these series, the protagonists try to just do that. In addition, other characters join them in the cause of their rebellion.
There is comedy, drama, and hints of romance in the series. Both anime also contain supernatural elements as well as action. In Gurren Lagann, there's the little bonus of mecha and some Yoko action of course ;)
both being based around beast beings ruling over humans and lots of action as well too.
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Recommended by Disapeared_Ghost