 If you liked
Sakura-sou no Pet na Kanojo
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 ...then you might like
Komi-san wa, Comyushou desu.
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It involves a quiet yet exceptional main female protagonist who has a hard time with other people finding herself growing increasingly attached to a more average boy that understands and wants to help her.
These two are litarally the most similar animes. Both got a autistic girl and a guy that tries to help her. The comedy is also the same. You can't find a closer match than this
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Recommended by lil_rez_vert