 If you liked
Fullmetal Alchemist
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 ...then you might like
Tsubasa Chronicle
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I found that Kurogane reminded me a lot of Ed with his temper... The plot could be compared to FMA's as well-- the main characters spend the series looking for something, in this case memories in the form of feathers (not as bad as it sounds, I promise!) but they often get distracted by little subplots. Like fma, though, the subplots do not get in the way of the big picture.
The overall mood of the anime is quite similar. There is some humour in it, but behind that there is darkness and sadness.