Just don't skip the comedy episodes(because that's the Main thing about Gintama), because comedy episodes introduces the characters,gives backstory and characterisation,introduces villains, and sets up plot points that will be explored in 100-300 Episodes
like for Example, you meet this group called the "4 Devas" in comedy episodes, then 200 Episodes later there is a Full Blown Serious arc about the 4 Devas(and this Serious arcs is my 2nd favorite one in the series)
Skip Episodes 1 and 2(they were Filler for Manga readers back in 2006), and whenever you get to the First Serious arc...which is Episodes 58-61(watch Movie 1 instead of watching those episodes...the Remake movie has better Animation,added scenes, and Fight Scenes)
Watch "Gintama" bro, it's on it's Final arc in the manga right now, it's a comedy shonen, but it also has Serious arcs(that does action and serious moments better than most Battle Shonens)
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like for Example, you meet this group called the "4 Devas" in comedy episodes, then 200 Episodes later there is a Full Blown Serious arc about the 4 Devas(and this Serious arcs is my 2nd favorite one in the series)