American McGee's Alice

Shortly after her second adventure, Through the Looking-Glass, Alice's house is burned down by an accidental fire, killing her family, and leaving her as the only survivor. As time progresses Alice loses touch with reality. She is institutionalized in Rutledge Asylum, where she is observed and treated by Dr. Hieronymous Q. Wilson. Alice's only possession in Rutledge is a stuffed rabbit. Ten years after Alice was committed to Rutledge, she finds herself sucked back into a Wonderland that has been twisted by her own broken mind. The White Rabbit summons Alice to aid a radically altered Wonderland, which became a twisted version of itself as it came under the horrible rule of the Queen of Hearts. The Cheshire Cat serves as Alice's companion throughout the game, frequently appearing to guide her with cryptic comments.

Madness Returns takes place eleven years after the events of its predecessor, the same amount of time between the two games' releases. Alice has been released from Rutledge Asylum and into the care of a London psychiatrist, where the traumatic memories of her parents' deaths continue to haunt her. As a result of her relocation, her hallucinations and internal struggle have increased in severity, and she returns to Wonderland in hopes of security and comfort. However, it has once again become warped by her insanity, and she must save its residents and herself from the evil that is taking over Wonderland and also embarks finding the true cause of her family's mysterious deaths.