Kono Healer, Mendokusai

both are fantasy anime with boke tsukkomi comedy format kono healer is about adventurers, and its MC is male and female dekoboko is about witches, and has 2 female main characters 

Duo comedy full of roasting each other 

You have the straightman routine with two characters: one with Shinpachi in yorozuya, the other with Hijikata in the Shinsengumi.  

A 24-minute comedic fantasy comedy based entirely on a single (ridiculous) joke/premise, and features friendly "enemy" monsters. Unfortunately Kono Healer suffers from much worse pacing and poor comedic timing. 

Everything tells me that these shows are not funny whatsoever, but I can't help but smile to myself the whole time. There is no graphic potty humor or ecchi to be found. These are just cheesy jokes, gags, and situations your dad would love. Just characters that you grow to like against all odds and reason. 

More hilarious manzai humor in an RPG-style fantasy world-- what could be better? 😄 

The quality of animation might not be the best but the question is, Could anime be as enjoyable with great VA performance alone? This recommendation is my final answer. 

Both anime seem to present themselves a typical show of their respective genre However, they manage to subvert every single cliché and trope in their genre with refreshing dialog and good characters. Particularly, the dialog between the main two characters is outstanding. 

Both series parody the fantasy action adventure genre. The characters keep subverting the cliché tropes and sometimes break the 4th wall. Moreover, the authors added crazy plot twists that you will never predict. 

Manzai comedy anime with a large cast of voice actors and absurd premises 

Two adventure comedies set in a fantasy world where humans cohabit with monsters, tho in DnNnH the monsters don't live on the surface like the ones in KHM does. Their art styles are quite similar and have a bit of action in both but the directions in genre face differently despite having the same genres. KHM is very much more gag comedy and DnNnH's comedy isn't as crazy but there are still funny moments. DnNnH has more plot compared to which some may deem more heavy plus the use of blood too, although not entirely melodramatic serious. 

There is a hero in a fantasy world and everyone is making him as angery as possible. The main girl is very annoying, you'll either love her or hate her, no middle ground. Both shows parody the RPG genre.